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Instead, the SRY gene operates as a mas-ter switch that controls the cascade ofseveral gene activationson autosomes 9, 11, 17, and 19 and the X chromosome.A transcription factor called the testis-determining factor(TDF), encoded by the SRY gene, has a molecular domainthat binds into a specific region of DNA and alters it struc-ture. The higher the AUC,the better the prognostic marker

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